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Hair loss and genetics

Much research has gone into the genetic component of male pattern baldness, or androgenic alopecia (AGA). Research indicates that susceptibility to premature male pattern baldness is largely X-linked. Other genes that aren’t sex linked are also involved.

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Large studies in 2005 and 2007 stress the importance of the maternal line in the inheritance of male pattern baldness. German researchers name the androgen receptor gene as the cardinal prerequisite for balding. They conclude that a certain variant of the androgen receptor is needed for AGA to develop. In the same year the results of this study were confirmed by other researchers. This gene is recessive and a female would need two X chromosomes with the defect to show typical male pattern alopecia. Seeing that androgens and their interaction with the androgen receptor are the cause of AGA it seems logical that the androgen receptor gene plays an important part in its development.

Other research in 2007 suggests another gene on the X chromosome, that lies close to the androgen receptor gene, is an important gene in male pattern baldness. They found the region Xq11-q12 on the X-chromosome to be strongly associated with AGA in males. They point at the EDA2R gene as the gene that is mostly associated with AGA.

Other genes involved with hair loss have been found. One of them being a gene on chromosome 3. The gene is located at 3q26. This gene is recessive.

Another gene that might be involved in hair loss is the P2RY5. This gene is linked to hair structure. Certain variants can lead to baldness at birth, while another variant causes “wooly hair.”

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In May 2009, researchers in Japan identified a gene, Sox21, that appears to be responsible for hair loss in people.

sox21

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This entry was posted on Friday, October 2nd, 2009 at 10:30 am and is filed under HAIR LOSS FACTS, HAIR LOSS SCIENCE. Both comments and pings are currently closed.

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